The MTHFR Stack · $340 Value for $299 — Every Day
Methylation · Genetics
Everyone has the gene. 40% have the variant that changes everything.
It quietly breaks your methylation cycle — the system that controls your mood, your drive, your sleep, and how fast you age. Brain fog. Low motivation. Poor sleep. Emotionally flat. You've felt it. Now you know why.
Formulated by Nurse Doza·DC·RN·FNP-C
First Release
A $340 value for $299 — every day. Save $41.
Individual Total
$340
Bundle Price
$299
The bundle discount is applied automatically at checkout. $340 value for $299, every day.
Choose your Boost flavor
$340 value for $299 — every day
The Bundle
Three formulas built around one cycle. Bliss delivers methyl donors under the tongue. Boost delivers B vitamins already in their active, methylated forms. Liver Boost supports the detox pathways the cycle feeds into.*
The Variant
MTHFR is a gene everyone carries. But 40% of people carry a variant that compromises their ability to convert folate into usable methyl groups. That means their methylation cycle runs at reduced capacity — regardless of how well they eat or how many vitamins they take. Standard supplements don't solve this. They require the same conversion your body is already struggling to make. Every form in the Stack was chosen to skip that step.
"40% of people. One gene. Every symptom you've been chasing."
The System Underneath
Your methylation cycle is your body's master switching system. It controls serotonin production, dopamine, melatonin, liver detox function, and your DNA expression. When it runs low on methyl donors — everything downstream goes offline. Not dramatically. Just quietly. Just enough to make you feel like a slightly worse version of yourself.
Calm · emotional regulation
Drive · motivation · focus
Deep sleep · cellular repair
Phase I + II detox · hormone clearance
Steady output · the 2pm test
Your cells' energy production runs on B vitamins the cycle activates. When methylation lags, energy is usually the first thing to go quiet.
The Energy Connection
Thousands of people drink Boost every morning as their energy drink. Most never asked why it's the one supplement they actually notice. Part of the answer is the forms: methylcobalamin B12 (2,500 mcg) and Quatrefolic® 5-MTHF folate — B vitamins that arrive already converted, so a compromised conversion step doesn't stand between you and them. 95 mg of clean, slow-release caffeine. Zero sugar. In the Stack, Boost is the morning leg of the cycle.*
The Stack
Raw material in. Cofactors already active. Everything downstream, supported.
01
SAMe (400 mg) and TMG (600 mg) in sublingual form. Direct methyl donors — no digestion, no conversion required. Supports neurotransmitter synthesis and a healthy mood.*
02
The one so many customers use as their daily energy drink. Methylcobalamin B12 (2,500 mcg) and Quatrefolic® 5-MTHF folate — B vitamins already in their methylated, active forms. With electrolytes and antioxidants to support healthy energy. Contains 95 mg caffeine.*
03
Everything the cycle feeds into. Supports phase I and phase II liver detoxification, glutathione production, and healthy estrogen and testosterone metabolism. It also carries 240 mcg DFE of 5-MTHF — six times the methylated folate in a stick of Boost — so the downstream support comes with more of the cycle's key cofactor.*
Diagnostic
Before You Buy
A methyl donor is a molecule that supplies methyl groups (a carbon atom bonded to three hydrogens) to your methylation cycle. Your body uses these methyl groups in neurotransmitter synthesis, gene expression, hormone detoxification, and melatonin production. SAMe and TMG — the two active ingredients in Bliss, the shot inside The MTHFR Stack — are the most direct methyl donors available.*
Standard B vitamins require your body to perform a series of conversions before they can donate a methyl group. If you carry the MTHFR variant, those conversions run at reduced capacity. The Stack works around that bottleneck: sublingual methyl donors in Bliss, already-methylated B vitamins in Boost, and phase I and II liver support in Liver Boost.*
Stack Reviews
BLISS
"One of my fave supplements out there! I've tried other forms of SAMe and TMG and it's just not the same as Bliss. I have a slow COMT so this supp is a game changer for me. I'm a functional nutritionist and recommend this to clients as my preferred SAMe supplement."
Tara
Functional Nutritionist · Verified Customer
BLISS
"Bliss is a total game changer — totally makes my workday that much more effective, in that my brain fog is reduced. This is coming from someone who has tried it all."
Mallory N.
Verified Customer
BOOST
"By far my favorite supplement of all time — it's my everyday energy drink. I don't like how coffee makes me feel, but with Boost I have tons of energy right after I drink it, and no crash afterward. My wife and I never travel without it. Did I mention it's delicious?"
Jon
Verified Buyer
BOOST
"I absolutely love Boost. It gives me a clean feeling of energy and clarity without the harsh taste of vitamins. I get the berry and love the taste."
Cortnie F.
Verified Buyer · Mixed Berry
LIVER BOOST
"I think it's been about a year that I've been taking Liver Boost. I feel more energetic, poops happen every day, and it's helped with my sugar cravings. This is by far their best product!"
Christina M.
Verified Purchase
LIVER BOOST
"Great product! I started taking because I had my gall bladder taken out years ago. I stopped taking it for a while, but noticed a difference immediately when I got back on them. I feel better and have more energy!"
Christy S.
Verified Purchase
The Formulator
Nurse Doza is a Doctor of Chiropractic, Registered Nurse, and Family Nurse Practitioner. He knew exactly what the methylation cycle needed — direct methyl donors, B vitamins already in their active forms, and liver support downstream. The MTHFR Stack is what he built for it.
Presenting the methylation science live at the Beyond Biohacking Conference·Austin, TX·May 2026
Questions
The MTHFR Stack — $299·$340 Value·Save $41
